fig3

Figure 3. Comparative analysis of gene co-mutation patterns in CRC patients carrying or not BRAF mutations. (A and B) Oncoprint of gene mutations (cutoff 5%) indicating co-mutations or mutual exclusivity patterns in BRAF-mutant CRC patients of cohort #1 (A) and cohort #2 (B); (C and D) Bar plot of the number of BRAF-mutant CRC patients of cohort #1 (C) and cohort #2 (D) with mutational overlap. The spots under the bar plot show the presence of mutually exclusive or co-occurrence mutations (highlighted in blue and red, respectively). On the right, for each mutated gene, the table indicates the association parameters and statistical significance; (E) OS in CRC patients carrying BRAF mutations and co-occurrent mutations in SMAD4 (magenta), PIK3CA (blue), and FBXW7 (green) on Kaplan-Meier graphs; (F and G) Box plots showing mutation count (F) and TMB (G) in CRC patients carrying co-occurrent mutations in BRAF oncogene and ATM, SMAD4, PIK3CA or FBXW7 genes. CRC: Colorectal cancer; OS: overall survival; TMB: tumor mutational burden; ATM: ataxia-telangiectasia mutated.