fig1

Figure 1. Workflow of pan-cancer analysis of BRAF alterations across tumor types. Workflow of the analysis on the genomic data sets to evaluate - across multiple cancer types - the frequency of BRAF alterations (point mutations, deletions/amplifications and structural variants), associations with molecular/clinical features and mutational co-occurrence. Tumors were selected on a mutation frequency cutoff of 5% from the TCGA and non-TCGA datasets in cBioPortal. Cohort descriptions are provided in the main text and in the Methods section.