fig6

Figure 6. Modulation of lipid nanomicellar delivery system for overcoming cancer drug resistance. (A) In vitro cellular uptake of RGD-DTX-M by MDA-MB-231 cells. ^**P < 0.01; ^****P < 0.0001. This figure is quoted with permission from Chen et al.^[138]; (B) Diagram depicting the biodegradable pH-sensitive micellar systems and elucidation of the in vivo tumor targeting and mechanisms underlying the anti-MDR effect. This figure is quoted with permission from Gao et al.^[137]; (C) The alteration in zeta potential observed in various formulations of pH-responsive PHIS-PEG2000 and DSPE-PEG2000 hybrid micelles. This figure is quoted with permission from Gao et al.^[137]; and (D) Schematic representation of multifaced lipid and micelle formulation employed in HCC. This figure is quoted with permission from Wu et al.^[116]. RGD: (Arg-Gly-Asp) peptides; DTX: docetaxel; MDA-MB-231: human triple negative breast cancer cell line; MDR: multidrug-resistant; HCC: hepatocellular carcinoma.