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Figure 3. Strategies for overcoming resistance in ADC therapy. The illustration highlights three key approaches: redesigning ADCs with next-generation linkers and payloads, identifying biomarkers for personalized treatment, and implementing combination therapies with endocrine therapy, immunotherapy, chemotherapy, and radiotherapy. These strategies aim to optimize therapeutic outcomes and address resistance mechanisms. Created in BioRender. Larose, E. (2024) https://BioRender.com/f12z842. ADC: Antibody-drug conjugate.