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Figure 2. The distribution and prognostic value of YAP1-positive cells in ES-SCLC. (A) High-level YAP1-positive cells infiltrated; (B) Low-level YAP1-positive cells infiltrated. The fluorescence signal channels corresponding to each image are indicated in the bottom left corner of each figure. The tumor parenchyma and stromal regions are divided based on PanCK staining through mIHC; (C and D) The cell population and the cell density of YAP1-positive cells in responder and non-responder groups, as well as in tumor parenchyma and stroma, are shown. NS: P > 0.05, ^*P < 0.05; (E and F) The linear regression fitting curve calculated by Spearman correlation between PFS and cell population and cell density of YAP1-positive cells, respectively. ES-SCLC: Extensive-stage small-cell lung cancer; mIHC: multi-immunohistochemistry; PFS: progression-free survival.