fig2

Figure 2. LncRNAs that regulate 5-FU resistance in GI cancers. GI: Gastrointestinal; 5-FU: 5-fluorouracil; lncRNAs: long non-coding RNAs; miRNAs: microRNAs; CNBP: cellular nucleic acid binding protein; MTHFR: methylenetetrahydrofolate reductase; HMGA2: high mobility group AT-Hook 2; GPAM: glycerol-3-phosphate acyltransferase, mitochondrial; DPYD: dihydropyrimidine dehydrogenase; EPHA2: EPH receptor A2; SIRT1: sirtuin 1; NF-kB: nuclear factor-kappa B; TYMS: thymidylate synthase; HIF-1α: hypoxia-inducible factor-1α; Bcl-2: B-cell lymphoma-2; CREB1: CAMP responsive element binding protein 1; ZNF281: zinc finger protein 281; EIF5A2: eukaryotic translation initiation factor 5A2; PTBP1: polypyrimidine tract binding protein 1; SMC4: structural maintenance of chromosomes 4; SHOC2: SHOC2 leucine rich repeat scaffold protein; MTHFR: methylenetetrahydrofolate reductase; MST1: macrophage stimulating 1; KEAP1: Kelch-like ECH-associated protein 1; PDCD4: programmed cell death factor 4; PCB: pyruvate carboxylase.