fig1

Figure 1. MiRNAs that regulate 5-FU resistance in GI cancers. 5-FU: 5-fluorouracil; GI: gastrointestinal; miRNAs: microRNAs; CRC: colorectal cancer; PC: pancreatic cancer; HCC: hepatocellular carcinoma; GC: gastric cancer; EC: esophageal cancer; CCA: cholangiocarcinoma; BIM: Bcl-2-interacting mediator of cell death; CHK1: checkpoint kinase 1; WEE1: WEE1 G2 checkpoint kinase; HIF-1α: hypoxia-inducible factor-1α; MST1: macrophage stimulating 1; PDCD4: programmed cell death factor 4; PTEN: phosphatase and tensin homolog; PCDH20: protocadherin 20; KEAP1: Kelch-like ECH-associated protein 1; ING4: Inhibitor of growth family member 4; DKK2: dickkopf WNT signaling pathway inhibitor 2; DUSP2: dual specificity phosphatase 2; SOCS1: suppressor of cytokine signaling 1; SOCS3: suppressor of cytokine signaling 3; RB1: RB corepressor 1; DUSP6: dual-specificity phosphatase 6; CMPK1: cytidine/uridine monophosphate kinase 1; TYMS: thymidylate synthase; DPYD: dihydropyrimidine dehydrogenase; ZEB1: zinc finger E-box binding homeobox 1; E2F3: E2F transcription factor 3; Bcl-2: B-cell lymphoma-2; XIAP: X-linked inhibitors of apoptosis; BTG1: B-cell translocation gene 1; PTN: pleiotrophin; FZD7: Frizzled homolog protein 7; EIF4E: eukaryotic translation initiation factor 4E; HOXA13: Homeobox A13; Id-1: inhibitor of DNA binding 1; RAD18: RAD18 E3 ubiquitin protein ligase; PKM2: pyruvate kinase M2; FOXMI: Forkhead Box M1; VIM: vimentin; Mcl-1: MCL1 apoptosis regulator; HK II: Hexokinase II; TGFBR2: transforming growth factor beta receptor 2; ZBTB7A: zinc finger and BTB domain containing 7A.