fig2
Figure 2. Non-coding RNAs involved in the development of temozolomide resistance in GBM. Under regular conditions, miR-29c binds to the mRNA of SP1 and induces its degradation. However, the downregulation of miR-29c in GBM leads to increased abundance in SP1 mRNA and elevated SP1 protein expression, which in turn induces the expression of the MGMT gene. Additionally, the overexpression of the lncRNA TALC leads to a decreased abundance of miR-20b-3p. This attenuates the inhibition that miR-20b-3p exerts over the expression of c-MET, resulting in c-MET overexpression and subsequent downstream signaling to augment MGMT expression. The increased MGMT expression induced by these mechanisms ultimately augments the GBM cells’ ability to resist treatment with TMZ.
