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From: Reprogrammed lipid metabolism in advanced resistant cancers: an upcoming therapeutic opportunity
Figure 8. Paracrine signaling by TME on cancer cells. Cell subpopulations within the TME (ADSC, CAA, EPC) produce factors that support malignancy and drug resistance in cancer cells. Created with BioRender.com. TME: Tumor microenvironment; ADSC: adipose-derived stem cell; CAA: cancer-associated adipocytes; EPC: endothelial progenitor cell; NRG1: neuregulin 1; CXCL5: C-X-C motif chemokine ligand 5; FAM3C: metabolism-regulating signaling molecule C; CXCL8: CXC motif chemokine ligand 8; CCL2: CC motif chemokine ligand 2.
