fig7
From: Reprogrammed lipid metabolism in advanced resistant cancers: an upcoming therapeutic opportunity
Figure 7. Uptake of FFAs promotes chemoresistance. Uptake of FFAs promotes FAO. Acetyl-CoA, a major product of FAO, increases phospholipid levels in mitochondria and improves their integrity. Upregulated FABP4 increases FAO and makes cancer cells more resistant to chemotherapy. Created with BioRender.com. FFA: Free fatty acids; FAO: β-fatty acid oxidation; FABP4: fatty acid-binding protein 4; ACSL4: long-chain acyl-CoA synthetase 4.
