fig5
From: Reprogrammed lipid metabolism in advanced resistant cancers: an upcoming therapeutic opportunity
Figure 5. ACC1 and FASN as potential therapeutic targets for overcoming treatment resistance. A simplified representation of Fa synthesis provides phospholipids for the cell membrane. ACC1 is a critical enzyme in the carboxylation of acetyl-CoA to malonyl-CoA. Malonyl-CoA is then converted by FASN to palmitate, a saturated FA. Palmitate undergoes additional modifications, resulting in the production of SFA and MUFA. ACC1: Acetyl-CoA carboxylase 1; FASN: fatty acid synthase; FA: fatty acid; HER2: epidermal growth factor receptor 2; MHC-I: major histocompatibility complex class I.
