fig6

Figure 6. Ferroptosis resistance induced by alterations in lipid metabolism. PUFA is required for lipid peroxidation and ferroptosis, while the uptake and synthesis of MUFA contribute to ferroptosis resistance. Other pathways like lipid synthesis, cholesterol metabolism, and lipid droplet formation also determine the cancer cell sensitivity to ferroptosis. A939572 and MK-8245, SCD1 inhibitors; Betulin, a SREBP2 inhibitor; SB431542, a Smad2/3 inhibitor. PUFA: Polyunsaturated fatty acid; MUFA: monounsaturated fatty acid; SCD1: stearoyl-CoA desaturase 1; SLC7A11: solute carrier family 7 member 11; TIGAR: TP53-induced glycolysis regulatory phosphatase; ASS1: argininosuccinate synthase 1; SREBP1: sterol regulatory-element-binding protein 1; PDK4: pyruvate dehydrogenase kinase 4; ACSM1/3: acyl-CoA synthetase medium chain family member 1/3; SLC27A4: solute carrier family 27 member 4; IL4/13: interleukin 4/13; JAK: Janus kinase; STAT6: signal transducer and activator of transcription 6; 15-LOX: 15-lipoxygenase; PUFA: polyunsaturated fatty acid.