fig5

Figure 5. Ferroptosis resistance induced by the activation of NRF2 antioxidant response. NRF2 protein expression is modulated by CYBB, ATF3, p-SRC, DPP9, ABCC5, and NSUN2. Moreover, NRF2 promotes ferroptosis resistance by transcriptionally upregulating several target genes, including CBS, SLC7A11, GPX4, HOMX1, FTH, MT1G, and SOD. SLC7A11: Solute carrier family 7 member 11; GPX4: glutathione peroxidase 4; GSH: glutathione; CYBB: cytochrome b-245 beta chain; CBS: cystathionine beta-synthase; FTH: ferritin heavy chain; SOD: superoxide dismutase; ABCC5: ATP binding cassette subfamily C member 5; MT1G: metallothionein 1G; DPP9: dipeptidyl peptidase 9; ATF3: activating transcription factor 3; NSUN2: NOP2/Sun RNA methyltransferase 2; NRF2: NFE2-like bZIP transcription factor 2; NFE2: nuclear factor, erythroid 2; HOMX1: heme oxygenase 1.