fig4

Figure 4. Ferroptosis resistance induced by the activation of the CoQ pathway. FSP1- or DHODH-mediated generation of CoQH₂ functions as a key component in cellular antioxidant systems, contributing to ferroptosis resistance in cancer cells. Brequinar, a dual inhibitor of FSP1 and DHODH; Novobiocin, a POLQ inhibitor. FSP1: Ferroptosis suppressor protein-1; DHODH: dihydroorotate dehydrogenase. POLQ: polymerase theta; NRF2: NFE2-like bZIP transcription factor 2; NFE2: nuclear factor, erythroid 2; ACSL1: acyl-CoA synthetase long-chain family member 1; AHR: aryl hydrocarbon receptor; ALDH1A3: aldehyde dehydrogenase 1 family member A3; TRIM21: tripartite motif-containing 21; KEAP1: kelch-like ECH-associated protein 1; PRR11: proline-rich protein 11; CEBPB: CCAAT enhancer binding protein beta; PRR11: proline-rich protein 11; E2F4: E2F transcription factor 4.