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Figure 3. Intercellular crosstalk between cancer-associated adipocytes and ovarian cancer cells. Adipocyte secretions promote metastasis and chemoresistance. Adipocytes release free fatty acids, which are taken up by the tumor cells and are metabolized through fatty acid oxidation, which promotes chemoresistance. STAT3: Signal transducer and activator of transcription 3; CPT1B: carnitine palmitoyltransferase 1B; IGF-1: insulin-like growth factor-1; TIMP1: tissue inhibitors of metalloproteinases 1; MCP-1: monocyte chemoattractant protein-1; Akt: protein kinase B.