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Figure 2. Intercellular crosstalk between the predominant M2 TAMs and ovarian cancer cells. Cisplatin activates M2 TAMs to secrete exosomes and cytokines (IL-10, CCL17, CCL22) that activate chemoresistance mechanisms in ovarian cancer cells. Specifically, the cytokine CXCL16 interacts with the CXCR6 receptor, increasing WTAP and YTHDF1 and decreasing ALKBH5 expression. This results in increased DNA repair mechanisms and leads to chemoresistance. WTAP: Wilms tumor 1-associated protein; YTHDF1: YTH N6-methyladenosine RNA binding protein F1; ALKBH5: alkB homolog 5; CXCR6: C-X-C chemokine receptor type 6; CXCL16: C-X-C chemokine ligand 16; IL-10: interleukin-10; CCLs: chemokine (C-C motif) ligands; FGF9: fibroblast growth factor-9; TAMs: tumor-associated macrophages.