fig2
From: HER3-targeted therapy: the mechanism of drug resistance and the development of anticancer drugs
Figure 2. HER3 is involved in drug resistance in the treatment processes of different cancers. The dimerization of HER3 with HER2 or EGFR is involved in the resistance of multiple drugs in cancer-targeted therapy. In addition, HER3 also participates in multidrug resistance in cancer chemotherapy, hormonal therapy, and radiotherapy resistance. HER: Human epidermal growth factor receptor; ER: estrogen receptor; AR: androgen receptor; EGFR: epidermal growth factor receptor.
