fig2

Figure 2. Summary of reported roles and mechanisms of class I and class IIa HDACs in different cancer cell lines that respond to treatment with cisplatin. Mechanisms of resistance are shown in purple, while mechanisms of susceptibility are shown in light orange. The relationships between HDAC4 and TP53 are poorly defined (question marks). In addition, the existence of different multiprotein complexes with class I and IIa HDACs is also considered. BIK is a BH3-only pro-apoptotic BCL2 family member. For details, please refer to the text. HDACs: Histone deacetylases; BIK: BCL2 interacting killer; BCL2: B-cell CLL/lymphoma 2.