fig1

Figure 1. AlphaFold prediction of Class I and Class IIa structures discussed in this review (Q13547; Q92769; O15379; P56524; Q9UQL6. Q8WUI4; Q9UKV0). The different views were similarly oriented, taking as reference the eight-stranded parallel β-sheet of the common deacetylase domain. The colors indicate the different per-residue confidence scores (pLDDT). Some regions below 50 pLDDT may be unstructured in isolation. For details, see https://alphafold.ebi.ac.uk. pLDDT: Predicted Local Distance Difference Test.