fig7
![Isocucurbitacin B inhibits glioma growth through PI3K/AKT pathways and increases glioma sensitivity to TMZ by inhibiting hsa-mir-1286a](https://image.oaes.cc/f7feab68-5c6b-49da-a16d-a6f35b649abb/cdr7001.fig.7.jpg)
Figure 7. (A) Protein expressions of p-PI3K, PI3K, p-AKT(S473), t-AKT, RXRα, PDK1, p-MAPK1/3, MAPK1/3 and Bcl-2 were analyzed using WB. Data are represented as mean ± SD (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 vs. control group); (B) Protein expressions of p-STAT3, STAT3 were analyzed using WB. Data are represented as mean ± SD (**P < 0.01 vs. control group). PI3K: Phosphoinositide 3-kinase; AKT: AKT serine/threonine kinase; PDK1: 3-phosphoinositide-dependent protein kinase 1; MAPK: mitogen-activated protein kinase; WB: western blot; STAT3: signal transducer and activator of transcription 3.