fig5
![Isocucurbitacin B inhibits glioma growth through PI3K/AKT pathways and increases glioma sensitivity to TMZ by inhibiting hsa-mir-1286a](https://image.oaes.cc/f7feab68-5c6b-49da-a16d-a6f35b649abb/cdr7001.fig.5.jpg)
Figure 5. (A and B) The transwell invasion process is measured by the number of cells after 24 h of treatment (**P < 0.01, ***P < 0.001 vs. control group); (C and D) Protein expressions of MMP-2/9, N-cadherin, and Vimentin were analyzed using WB. Data are represented as mean ± SD (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 vs. control group vs. control group); (E) Expression of MMP-2 and MMP-9 RNA was detected using RT-qPCR (*P < 0.05, **P < 0.01, ***P < 0.001 vs. control group). MMP-2/9: Matrix metalloproteinase 2/9; WB: Western blot; RT-qPCR: reverse transcription-quantitative polymerase chain reaction.