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![Mechanisms of tyrosine kinase inhibitor resistance in renal cell carcinoma](https://image.oaes.cc/ff5b21f2-a742-49b6-962d-5efd530e2e55/cdr6089.fig.1.jpg)
Figure 1. Common receptor tyrosine kinases and their downstream signaling targets. ABC: ATP-binding cassette; ERK: extracellular signal-related kinases; FGF: fibroblast growth factors; FGFR: FGF receptor; HGF: hepatocyte growth factor; mTOR: mammalian target of rapamycin; PDGFR: platelet-derived growth factor receptor; PI3K: phosphoinositide-3-kinase; TKIs: tyrosine kinase inhibitors; VEGF: vascular endothelial growth factor; VEGFR: vascular endothelial growth factor receptor.