fig5
Figure 5. A therapeutic strategy focused on metabolic vulnerabilities and nutrient addiction: glutamine metabolism. Effects of xCT on ferroptosis in the absence (A) or presence (B) of glutaminase inhibitor. GLUT1/SLC2A1: Glucose transporter 1; GSH: glutathione; NADPH: nicotinamide adenine dinucleotide phosphate; PPP: pentose phosphate pathway; ROS: reactive oxygen species; xCT: cystine/glutamate antiporter SLC7A11.
