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From:  A comprehensive overview of recent developments on the mechanisms and pathways of ferroptosis in cancer: the potential implications for therapeutic strategies in ovarian cancer
A comprehensive overview of recent developments on the mechanisms and pathways of ferroptosis in cancer: the potential implications for therapeutic strategies in ovarian cancer

Figure 4. A therapeutic strategy focused on metabolic vulnerabilities and nutrient addiction: PDK-dependent metabolism. Effects of xCT on ferroptosis in the absence (A) or presence (B) of erastin or PDK inhibitor. DCA: Dichloroacetate; GLUT1/SLC2A1: glucose transporter 1; PDK: pyruvate dehydrogenase kinase; PDH: pyruvate dehydrogenase; ROS: reactive oxygen species; TCA: tricarboxylic acid; VDAC: voltage-gated anion channels; xCT: cystine/glutamate antiporter SLC7A11.

Cancer Drug Resistance
ISSN 2578-532X (Online)
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