fig4
Figure 4. A therapeutic strategy focused on metabolic vulnerabilities and nutrient addiction: PDK-dependent metabolism. Effects of xCT on ferroptosis in the absence (A) or presence (B) of erastin or PDK inhibitor. DCA: Dichloroacetate; GLUT1/SLC2A1: glucose transporter 1; PDK: pyruvate dehydrogenase kinase; PDH: pyruvate dehydrogenase; ROS: reactive oxygen species; TCA: tricarboxylic acid; VDAC: voltage-gated anion channels; xCT: cystine/glutamate antiporter SLC7A11.
