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Figure 2. Mechanisms of T cell evasion in AML. T cells engage with and kill cancer cells through the presentation of MHC molecules and subsequent T cell co-stimulation (left). Mechanisms to evade T cell detection employed by AML cells include (1) increased expression of co-inhibitory immune checkpoints; (2) decreased MHC expression; and (3) suppression of cytotoxic CD8+ T cell function through increased regulatory T cells (right). Figure created with Biorender.com. AML: Acute myeloid leukemia; CTLA4: cytotoxic T lymphocyte antigen 4; IFNγ: interferon gamma; MHC: major histocompatibility complex; PD1: programmed cell death protein 1; PFN: perforin; TCR: T cell receptor; TIM3: T cell immunoglobulin and mucin domain-containing protein 3; TNFα: tumor necrosis factor alpha.