fig1
From: Recent advances in access to overcome cancer drug resistance by nanocarrier drug delivery system
Figure 1. This diagram depicts the expulsion of cells by efflux transporters, including P-gp, BCRP, and MRP-1. Other mechanization includes drug inactivation by increasing the expression of enzymes that metabolize drugs and the development of resistance. Cells can develop resistance by changing the target of a drug, thus disabling the drug. Drug isolation into lysosomes can cause drug inactivation and cause cancer cells to acquire resistance. Drugs inhibit cell apoptosis and produce drug resistance by interfering with the genetic cycle of cells. BCRP: Breast cancer resistance protein; Bcl-2: B-cell leukemia protein 2; MRP: multidrug resistance-related protein; P-gp: p-glycoprotein.
