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Figure 2. (A) Schematic diagram of drug transport in chemoresistance in OC. ABC transporters such as ABCB1, ABCC1, ABCC2, ABCC4, ABCC10, and ABCG2, P-type ATPase ATP7A, and SLC transporter CTR2 responsible for drug efflux are upregulated, while SLC transporter CTR1 that functions for drug influx is downregulated, and P-type ATPase transporter ATP7B does not directly facilitate drug efflux, but its genetic polymorphism can influence drug efflux; (B) OCSCs confer chemoresistance in OC. OSCs are transformed into OCSCs due to genetic alteration, which then proliferate into progenitor cells and subsequently differentiate into cells that contribute to the relapse of ovarian tumors after some time instead of undergoing cell death upon chemotherapy. Created with BioRender.com. OC: Ovarian cancer; ABCB1: ATP-binding cassette subfamily B member 1; ABCC: ATP-binding cassette subfamily C; ABCG2: ATP-binding cassette subfamily G member 2; SLC: solute carrier; CTR1/2: copper transporter 1/2; OCSCs: ovarian cancer stem cells.