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![Dysregulation of calcium homeostasis in cancer and its role in chemoresistance](https://image.oaes.cc/c69be3d0-c244-445d-8c74-bad72470a04d/cdr60145.fig.2.jpg)
Figure 2. Apoptosis inhibition in cancer cells. Increased Ca2+ influx through upregulated VGCC, TRP, and ORAI1-ORAI3 heterodimer leads to activation of CAMKII, which inhibits pro-apoptotic caspases 8 and 9. Downregulation of ORAI1 monomer and SERCA reduces