fig1
![The therapeutic potential of circular RNA in triple-negative breast cancer](https://image.oaes.cc/29ee7a30-4a3d-48ae-8c66-e672b8afea66/cdr60141.fig.1.jpg)
Figure 1. Biosynthetic mechanisms for circRNAs. (A) Lariat-driven circularization: lariat causes exons or introns that were originally far apart to come closer; (B) Intron pairing-driven circularization: complementary sequences in introns promote circRNA circularization by base pairing to bring the 3' splice acceptor site and the 5' splice donor site closer together in spatial conformation; (C) RBP-dependent circularization: RBPs bind to intronic sequences or specific motifs within flanking introns near the splice site and indirectly bridge the distance between upstream and downstream exons. RBP: RNA binding protein.