fig6
Figure 6. Effect of the docetaxel-elacridar combination in the docetaxel-resistant DU-145DOC10 cell line in the 3D clonogenic assay. (A) Concentration-effect curve showing a decrease of the docetaxel IC50 from 11.4 to 1.9 nM combined with 1 μM elacridar and from 11.4 to 1.6 nM combined with 1 μM elacridar; (B) Bliss Modeled T/C analysis shows synergistic effects at both test concentrations of elacridar (0.316 and 1 µM) when combined with medium concentrations of docetaxel (3.16 and 10 nM).
