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Figure 2. Double volcano plot of differential gene expression between the parental human prostate cancer cell lines DU-145 and 22Rv1 and their docetaxel resistance generated clones DU-145DOC10 and 22Rv1DOC8. Red dots are differentially expressed genes between DU-145 vs. DU-145DOC10, blue for 22Rv1 vs. its resistant clone 22Rv1DOC8. Green dots are differentially expressed genes in both setups. The grey area represents not significantly regulated genes. Cut-offs of 2-fold and a FDR P < 0.05 were used. Note the extreme differentially and significantly expressed green dot for MDR1 (arrow). FDR: False detection rate; MDR1: multidrug resistance protein 1.