fig3

Figure 3. Drug resistance of ECs by tumor-derived EVs. Metastatic melanoma-derived EVs are taken up by ECs. Then, miR-1246 enhances IL-6 expression by targeting AR. An autocrine system is utilized to induce drug resistance via phosphorylation of Akt and activation of STAT3. This figure is a modification of the schema in^[78]. ECs: Endothelial cells; EVs: extracellular vesicles; AR: androgen receptor; STAT3: signal transducer and activator of transcription 3.