fig2

Figure 2. Drug resistance is conferred to other cells through tumor-derived EVs. Drug-resistant tumor cells confer drug resistance to recipient cells by transporting mRNAs for ABCB1 and ABCC1, miRNAs involved in signaling such as Akt, and drug efflux transporters and P-gp modulators via EVs. EVs: Extracellular vesicles; ABCB1: ATP-binding cassette subfamily B member 1; ABCC1: ATP-binding cassette subfamily C member 1; P-gp: P-glycoprotein.