fig1
Figure 1. Schematic of the stages of autophagy. (A) Phagophore formation triggered by Beclin-1/VPS34 in response to a stress signal; (B) Multimerization resulting from ATG5/ATG12 conjugation and interaction with ATG16; (C) Embedding in the phagophore membrane by LC3 engraving; (D) Autophagosome formation by ATG4-directed LC3-II/ATG8 recycling; (E) Fragmentation of molecules following association with lysosome. ATG: Autophagy-related proteins.
