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![Loss of HER2 in breast cancer: biological mechanisms and technical pitfalls](https://image.oaes.cc/824dd236-47c2-452a-a5d8-667c374fec07/5243.fig.1.jpg)
Figure 1. HER2 downregulation, subtype switch, and clonal selection are biological mechanisms potentially responsible for HER2 loss. In parallel, technical pitfalls can cause false-negative results. Figure partly generated using Servier Medical Art, provided by Servier, licensed under a Creative Commons Attribution 3.0 unported license and adapted from Mathews et al.[13]