fig3
![Transcriptional coactivator MED1 in the interface of anti-estrogen and anti-HER2 therapeutic resistance](https://image.oaes.cc/23963ef2-37db-4c3c-abb4-fa0f268930a7/4752.fig.3.jpg)
Figure 3. Overcoming breast cancer therapeutic resistance by MED1 targeting multifunctional RNA nanoparticles. The figure shows the atomic force microscopy (A) and schematic (B) of the pRNA-HER2apt-MED1siRNA nanoparticle, its tumor-specific uptake in vitro and in vivo (C), and therapeutic effect to inhibit endocrine-resistant tumor growth (D), cancer stem cell formation (E), and lung metastasis (F) in vivo in an orthotopic xenograft mouse model. **P < 0.01, ***P < 0.001. Adapted from Zhang et al.[88], ACS Nano.