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Figure 1. Liquid biopsies in primary and secondary bone cancers. Cell-free ctDNA, CTCs, and EVs are released into the general circulation by both primary (osteosarcoma and Ewing sarcoma) and secondary (breast, lung, and prostate) cancers and can be collected with a simple blood draw. Studying these three cancer-derived components by molecular or cellular analysis is termed liquid biopsy. Much information about the tumor can be achieved by analyzing CTCs, ctDNA, and EVs, making liquid biopsies a minimally invasive alternative to classical biopsies. Created with BioRender.com. ctDNA: Circulating tumor DNA; CTCs: circulating tumor cells; EVs: extracellular vesicles.