fig1
From: Drug resistance in metastatic castration-resistant prostate cancer: an update on the status quo
![Drug resistance in metastatic castration-resistant prostate cancer: an update on the status quo](https://image.oaes.cc/b51530fb-1f47-45ee-bb79-62e1bb99e383/4774.fig.1.jpg)
Figure 1. Mechanisms of drug resistance in mCRPC. Several mechanisms of drug resistance are well defined in CRPC, including AR amplification and overexpression, AR point mutations, AR post-translational modifications, AR splice variants, AR co-regulators, altered steroidogenesis, GR overexpression, neuroendocrine differentiation, tumor microenvironment, and other signaling alterations. AR: Androgen receptor; GR: glucocorticoid receptor; mCRPC: metastatic castration-resistance prostate cancer.