fig1
From: The evolving role of DNA damage response in overcoming therapeutic resistance in ovarian cancer
Figure 1. A schematic representation of the DNA damage response and its interaction with cell cycle regulation. RPA binds to sites of ssDNA and co-localizes with ATR and its binding partner ATRIP. CHK1 is the effector of ATR and regulates cell cycle progression via induction of G2 arrest. Ovarian cancer cells with deficient p53 function have aberrant G1/S regulation and rely more heavily on G2/M regulation. Wee1 activates the G2/M checkpoint through phosphorylation of CDK1, a critical regulator for cells with deficient p53 function.
