fig1
![Resistance to energy metabolism - targeted therapy of AML cells residual in the bone marrow microenvironment](https://image.oaes.cc/cdf22abe-3701-4cbe-ba01-82707e02a491/5512.fig.1.jpg)
Figure 1. Energy metabolism in AML. Glucose is converted to pyruvate by glycolysis. Pyruvate is converted to acetyl-CoA for use in the tricarboxylic acid (TCA) cycle. ATP is produced by oxidative phosphorylation (OXPHOS) in the TCA cycle and electron transport chain (ETC). Fatty acid metabolism supplies acetyl-CoA to the TCA cycle via β-oxidation of fatty acids (FAO). Glutamine metabolism is the process of converting glutamine to glutamic acid. a-KG: Alpha-ketoglutarate; FAS: fatty acid synthase; OAA: oxaloacetic acid; ROS: reactive oxygen species.