fig1

Figure 1. Mitochondria involvement in colorectal cancer stem cells and drug resistance. (1) Reduced apoptosis due to lower Bax/Bak oligomerization and higher Bcl-2 expression. (2) Enhanced mitophagy with the participation of RAB7 and higher BNIP3L expression. (3) Addiction to OXPHOS with high mitochondrial membrane potential. The vectors used in the figure are from BioRender©. BNIP3L: BCL2 Interacting Protein 3 Like; CCSCs: colorectal cancer stem cells; OXPHOS: oxidative phosphorylation; RAB7: Ras-related protein 7.