fig2

Figure 2. Signaling pathways regulating CSCs and the use of inhibitors in suppressing these pathways. These molecules thereof could be developed as potential therapeutics. The denotes in the figure are: Hedgehog signaling pathway (HH), notch intracellular domain (NICD), phosphorylation (P), smoothened (SMO), Wnt signaling pathways (Wnt), nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkBα), RELA Proto-Oncogene (RelA), Frizzled (FZD), casein kinase I (CKI), Axin (AXIN), APC Regulator of WNT Signaling Pathway (APC), Dishevelled (Dvl), Glycogen Synthase Kinase (GSK), IkappaB Kinase (IKK).