fig2

Figure 2. Therapies targeting protein control pathways in multiple myeloma (MM). MM cells are highly dependent on a strictly regulated network of protein quality control pathways such as (A) the ubiquitin-proteasome system (UPS), (B) aggresome formation, (C) autophagy, (D) unfolded protein response, and (E) the heat shock response. Drugs that target these pathways are listed here: FDA-approved drugs (in red) and experimental drugs (in blue).