fig8
![Cellular irinotecan resistance in colorectal cancer and overcoming irinotecan refractoriness through various combination trials including DNA methyltransferase inhibitors: a review](https://image.oaes.cc/13431d71-f460-4517-8460-f6ce27fa1b55/4381.fig.8.jpg)
Figure 8. Cancer stem cells within a colorectal cancer tissue and drug resistance or drug sensitive phenotype. Tumorigenic cells in colon cancer existed as a high-density CD133+ population. Small population of CD133+ cells that are tumorigenic and drug resistant when subcutaneously implanted in immunodeficient mice reproduce the original tumor properties. In contrast, CD133- cells do not develop tumors and show drug sensitive phenotype. CSC: Cancer stem cell.