fig7
![SF3B1 modulators affect key genes in metastasis and drug influx: a new approach to fight pancreatic cancer chemoresistance](https://image.oaes.cc/22a5b35f-0321-42ea-9852-6a1c20d88173/4348.fig.7.jpg)
Figure 7. Increase of gemcitabine sensitivity in 3D models. (A) Representative images of PDAC-3 spheroids untreated (control) or treated with gemcitabine, IS4 or their combination (original magnification, 40×). (B) Effects of gemcitabine, IS4 or their combination on the areas of PDAC-3 spheroids after 72 h exposure. Columns, mean values obtained from triplicate experiments; bars, SEM; *P < 0.05 vs. control, ##P < 0.01 vs. gemcitabine.