fig2

Figure 2. Schematic of the activation of chimeric kinases. Normal monomeric, membrane bound, FGFR1, on binding ligand, dimerizes and is phosphoactivated but remains tethered to the membrane. In the absence of ligand FGFR1 remains an inactive monomer. Chimeric kinases are dimerized through the partner gene motif leading to ligand independent activation and constitutive downstream signaling.