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![DNA damage and metabolic mechanisms of cancer drug resistance](https://image.oaes.cc/f3efe87f-3abe-4ecc-bf0a-499bb69faaa0/4691.fig.2.jpg)
Figure 2. Lipid droplet usage in drug-resistant cells. Drug-resistant cells have been shown to increase lipid droplet accumulation (yellow circles) and have a higher percentage co-localized to the mitochondria, where an increase in PLIN4 helps to better utilize lipids for fatty acid beta-oxidation. Lipids can also be used as drug “sinks” for hydrophobic drugs. Figure created with BioRender.