fig1
![DNA damage and metabolic mechanisms of cancer drug resistance](https://image.oaes.cc/f3efe87f-3abe-4ecc-bf0a-499bb69faaa0/4691.fig.1.jpg)
Figure 1. PARPi synthetic lethality in BRCA 1/2 non-functional tumors. BRCA 1/2 functional tumor cells will repair the double-strand break (DSB) induced by PARP inhibition and sequential replicative stress allowing cell survival and growth, whereas BRCA 1/2 non-functional cells cannot repair the DSB and therefore succumb to DNA damage-induced cell death. Figure created with BioRender.