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![Microvesicles: the functional mediators in sorafenib resistance](https://image.oaes.cc/941c1bd5-5ac7-4604-90fd-2e0bc0030bd7/4789.fig.2.jpg)
Figure 2. The bidirectional role of TMVs in tumor development. TMVs derived from tumor cells could promote tumor progression via transferring cancerous molecules[13,62]. Simultaneously, they act as a functional regulator to modulate DC cells based on CD8+ T cell activation, which provokes cytotoxic T cell infiltration and inhibits tumor development[77]. Created with BioRender.com. TMVs: Tumor-derived microvesicles.