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![Venetoclax resistance: mechanistic insights and future strategies](https://image.oaes.cc/25af2e02-1da6-43c8-b591-2f06681370c8/4740.fig.3.jpg)
Figure 3. Both KRAS and PTPN11 mutations confer Venetoclax resistance. KRAS mutation causes upregulation of MCL-1 and BCL2A1, while PTPN11 mutation causes upregulation of MCL-1 and BCL-xL. KRAS mutation also downregulates BCL-2 and BAX[37].
Figure 3. Both KRAS and PTPN11 mutations confer Venetoclax resistance. KRAS mutation causes upregulation of MCL-1 and BCL2A1, while PTPN11 mutation causes upregulation of MCL-1 and BCL-xL. KRAS mutation also downregulates BCL-2 and BAX[37].
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